Research Grants

Current Funding

6/1/10 - 5/31/15

Role of NKCC1 on Brain Tumor Stem Cell Migration after EGF and Slit-2 Stimulation
R01NS070024
NIH/NINDS RO1
P.I.: Alfredo Quinones-Hinojosa; Effort 2.4 cal mos

1/1/11 - 6/31/16

Retrotransposon Instability in Glioblastoma Multiforme
R01NS070024
NIH/NCI RO1
P.I.: Jef Boeke
Role on Project: Co-investigator

8/1/06 - 12/31/11

Migration of Human Neural Stem Cells and their Transformation to Cancer Stem Cells
Howard Hughes Medical Institute Physician-Scientist Award
P.I.: Alfredo Quinones-Hinojosa; Effort 0.12 cal mos

1/1/08 - 1/1/12

Neural and Cancer Stem Cells: Study of Migration and Transformation
Robert Wood Johnson Foundation/Harold Amos Medical Faculty Development Program
P.I.: Alfredo Quinones-Hinojosa; Effort 0.6 cal mos

10/1/08 - 12/30/11

“Comparison of Utility of Different Functional MRI Language Paradigms for Effective Presurgical Mapping of Eloquent Cortex”
Siemens
P.I.: Jay Pillai
Role on Project: Collaborator; Effort 0.12 cal mos

7/1/09 - 6/30/12

The biology and therapeutic targeting of brain cancer stem cells
107017
The James S. McDonnell Foundation
P. I.: John Laterra and Alfredo Quinones-Hinojosa; Effort 0.6 cals mos

7/1/10 - 6/30/12

Stem Cell Transplantation in Non-human Primates with Parkinsonism
Maryland Stem Cells Research Fund (TEDCO)
P.I.: George Ricaurte
Role on Project: Co Investigator; Effort 0.12 cal mos

9/1/10 - 8/31/13

Atlas of gene expression by progenitor cells of the human brain and its tumors
NYSTEM
P.I.: Steven Goldman
Role on Project: Collaborator; Effort 0.12 cal mos

12/1/11 – 1/1/13

Cancer Stem Cells in Chordoma: Implications for Tumorigenesis and Treatment
Chordoma Foundation
P.I.: Alfredo Quinones-Hinojosa

7/1/11 – 6/30/14

Regulation of Neural and Neoplastic Stem Cells by Kruppel-like Transcription Factors
Maryland Stem Cells Research Fund (TEDCO)
P.I.: John Laterra
Role on Project: Sub-award P.I.

11/1/11 – 10/31/12

Headache Control for Patients Presenting with Intracranial Tumors
Neurosurgery Pain Institute at Johns Hopkins
P.I.: Alfredo Quinones-Hinojosa

5/1/10 – 12/31/11

Educational Grant – Vycor retractor
Vycor
P.I.: Alfredo Quinones-Hinojosa

Previous Funding

7/1/09 - 6/30/11

DNA Damage Response in Glioblastoma Stem Cells
106273
Maryland Stem Cell Research Fund (TEDCO)
P.I.: Mihoko Kai
Role on Project: Co-Principal Investigator; Effort 0.24 cal mos

6/01/09-5/31/11

Role of the Interaction between Cation-Chloride cotransporters and EGF and PDGF in Migration of Brain Tumor Stem Cells
106743
Maryland Stem Cell Research Fund (TEDCO)
P.I.: Tomas Garzon-Muvdi
Role on Project: Mentor

6/1/08 - 5/31/11

Molecular Mechanisms of Tumor-Propagation by Human Glioblastoma Stem Cells
104544
Maryland Stem Cell Research Fund (TEDCO)
P. I.: John Laterra
Role on Project: Co-Principal Investigator; Effort 0.84 cal mos

6/01/09-6/30/11

The effects of hypoxic adaptation and signaling on cancer stem cell growth and invasion
106916
Maryland Stem Cell Research Fund (TEDCO)
P.I.: Ahmed Moyheldin
Role on project: Mentor

6/30/08 - 6/29/11

Novel Micro and Nano Fluidic Platforms
103659
Control of Human Neural Stem Cell Survival, Proliferation and Differentiation Using
Maryland Stem Cell Research Fund (TEDCO)
P. I.: Andre Levchenko
Role on Project: Co-Principal Investigator; Effort 0.6 cal mos

6/30/08 - 6/29/11

Characterization of Anti-Glioma Response and Migratory Patterns of IL-12 Secreting
Human Mesenchymal Stem Cells
104268
Maryland Stem Cell Research Fund (TEDCO)
P.I.: Alfredo Quinones-Hinojosa; Effort 0.6 cal mos

7/1/06 - 6/30/11

Migration of Human Neural Stem Cells In Vitro and In Vivo
1K08NS055851
NIH/NINDS
P.I.: Alfredo Quinones-Hinojosa; Effort 2.4 cal mos

7/2008-6/2010

Extrinsic regulation of adult human neural and cancer stem cells in normal and disease states
Maryland Stem Cell Research Fund (TEDCO)
P.I.: Michael Bonaguidi
Role on Project: Co-Mentor; Effort cal mos

5/1/10-1/31/11

Polymeric Nanoparticles to Treat Brain Cancer
INBT
P.I.: Jordan Greene
Role on Project: Co-Investigator; Effort cal mos

2008-2010

Maryland Stem Cell Research Fund (TEDCO)
Guerrero- Cazares
Role on Project: Co-Investigator; Effort cal mos
Goal was to study the migration of human brain tumor stem cells in response to slit proteins

2009-2010

Sistema Nacional de Investigadores del Consejo Nacional de Ciencia y Tecnologia
National Researchers System of the Science and Technology Science Council
Quinones-Hinojosa (Mentor)

Summer 1993

Medical School Research Fellowship
Cornell University
Quiñones-Hinojosa (PI) 100%
Goal was to study the differences in suicide patterns between women and men in New York City

1993 – 1994

Honor’s Research Scholar (UC Berkeley)
Ford Baccalaureate Fellowship
Quiñones-Hinojosa (PI)20 %
Goal was to study long term potentiation and synaptic plasticity in the nucleus accumbens responsible for addictive behavior

Summer 1994

Health Professional Research Fellowship in Neurobiology
T32 NS07112-15S1
NIH- NINDS
David Potter (PI)100%
Goal was to learn molecular biology and clone the ecdysone receptor gene responsible for aggressive behavior in the American lobster Homarus Americanus

09/1994 – 12/1996

Research Training Grant Fellowship in Neurobiology
PO1 NS025915
NIH
Edward Kravitz (PI)20%
Goal was to learn molecular biology and clone the ecdysone receptor gene responsible for aggressive behavior in the American lobster Homarus Americanus

07/1997 – 06/1999

Medical Student Fellowship
Howard Hughes Medical Institute
Quiñones-Hinojosa (PI)100%
Goal was to study the role of neruoprotective agents on neuronal ischemia

12/1998 – 06/1999

Squibb Fellowship in Academic Medicine
Bristol-Myers- Massachusetts General Hospital Department of Neurosurgery and Harvard Medical School
Quiñones-Hinojosa (PI)100%
Goal was to study the effect of hypothermia in neuronal activity

07/2003 – 07/2004

Ruth L. Kirschstein Individual National Research Service Award
NIH 1 F32 NS 47011-01
NIH- NINDS
Quiñones-Hinojosa (PI)100 %
Goal was to study human neural stem cells and the cytoarchitecture of the human subventricular zone

01/2006 – 1/2007

Johns Hopkins University Passano Physician Scientist Award
Hopkins Medicine
Quiñones-Hinojosa (PI)100 %
Migration of Human Neural Stem Cells In Vitro and In Vivo.
The major goal of this project is to elucidate the subventricular zone (SVZ) cytoarchitecture of patients with brain cancer and to study the role of EGF in the migratory ability of stem cells derived from the human SVZ in these patients.

5/2006-6/2007

American Brain Tumor Association
ABTA
Quinones-Hinojosa (Mentor) 100%
The Phenotype of Migrating GBM Astrocytes

8/2006 - 7/2008

Association of American Medical Colleges-Nickens Fellowship
AAMC Nickens
Quinones-Hinojosa (PI)1%
Migration of Human Neural Stem Cells In Vitro and In Vivo
The major goal of this project is to address basic questions about the human brain, the cytoarchitecture, the precise location of stem cells, and molecular factors that regulate stem cell biology within the normal brain and in brain tumors

7/2007-6/2008

Howard Hughes Medical Institute
HHMI
Quinones-Hinojosa (Mentor) 100%
The Role of EGF in the Migration of Human Neural Stem Cells and Brain Tumor Stem Cells In Vitro and In Vivo
The primary goal of this study is to ascertain whether epidermal growth factor (EGF) stimulation can induce adult human neural stem cells (hNSCs) to migrate in a manner similar to that seen in glioblastoma multiforme (GBM) astrocytes. It is our hypothesis that hNSCs will transform into a more aggressive phenotype and migrate in a manner similar to that of BTSCs

7/2007-7/2008

American Association of Neurological Surgeons
AANS
Quinones-Hinojosa (Mentor)100%
The Role of PDGF and EGF in the Migratory Pattern of Brain Cancer Stem Cells and Comparison to Normal Fetal and Adult Human Stem Cells
The major goal of this project is to study stem cells in the human brain and consequently the effect that effect PDGF and EGF have on the migratory behavior of these stem cells. We will test the hypothesis that human adult stem cells have the ability to migrate and that their manipulation with PDGF and EGF can change them to a more aggressive migratory behavior that resembles that of high-grade tumors and/or the fetal human utilizing both in vitro and in vivo studies.

06/2008-05/2009

Howard Hughes Medical Institute
HHMI
Quinones-Hinojosa (Mentor)100%
The treatment of malignant gliomas using genetically modified adult Mesenchymal Stem Cells as a selective delivery vehicle for therapeutic agents

06/2008-05/2009

Howard Hughes Medical Institute
HHMI
Quinones-Hinojosa (Mentor)100%
Effects of platelet-derived growth factor receptor (PDGFR) signaling on tumor proliferation and progression from low-grade to high-grade

7/1/06-6/30/09

American Society of Clinical Oncology (ASCO) Foundation Award
ASCO
Quinones-Hinojosa (P.I.)
Migration of Human Neural Stem Cells In Vitro and In Vivo
The major goal of this project is to prospectively collect clinical data from patients with brain cancer (with authorization from patients and with approval from the University), to correlate the findings of cancer stem cells migratory ability to the final pathology and clinical outcome of patients.
Overlap: there is no budget overlap between this grant and the NIH KO8 grant. There is intellectual, scientific, and effort overlaps to the NIH KO8 grant.

7/1/06-6/30/08

American College of Surgeons Franklin Martin Faculty Research Award
ACS
Quinones-Hinojosa (P.I.)
Migration of Human Neural Stem Cells In Vitro and In Vivo
The major goal of this project is to address basic questions about the human brain, the cytoarchitecture, the precise location of stem cells, and molecular factors that regulate stem cell biology within the normal brain and in brain tumors.
Overlap: there is no budget overlap between this grant and the NIH KO8 grant. There is intellectual, scientific, and effort overlaps to the NIH KO8 grant.

7/1/06-6/30/09

Children’s Cancer Foundation
CCF
Quinones-Hinojosa (P.I.)
Isolation, Characterization, Migration, and Transformation to Cancer Stem Cells of Human Pediatric Subventricular Zone Neural Stem Cells
The major goal of this project is to study the pediatric human brain and to isolate pediatric human neural stem cells as well as cancer stem cells and to characterize their migratory ability in addition to studying the ability of these neural stem cells to transform to cancer stem cells in the pediatric population.
Overlap: there is no budget overlap between this grant and the NIH KO8 grant. There is very little intellectual, scientific, and effort overlaps to the NIH KO8 grant

4/1/06-3/31/09

Brain Tumor Founder Collaborative
BTFC
Quinones-Hinojosa (Co-P.I.)
Tumor Stem Cell-Based Drug Discovery for Adult and Pediatric Glioma
The major goal of this project is to perform hypothesis-driven and unbiased high through-put in vitro drug screens to identify agents with activity against a unique panel of adult and pediatric glioma stem cell lines.
Overlap: there is no budget overlap to NIH KO8 grant. There is minimal intellectual, scientific, and effort overlaps to NIH K08 grant.